Diabetes and brain disorders, a new role for insulin?
de Galan BE.
Neurosci Biobehav Rev. 2024 Aug;163:105775. doi: 10.1016/j.neubiorev.2024.105775. Epub 2024 Jun 18. PMID: 38901787.

Brain function in classic galactosemia, a galactosemia network (GalNet) members review.
Panis B, Vos EN, Barić I, Bosch AM, Brouwers MCGJ, Burlina A, Cassiman D, Coman DJ, Couce ML, Das AM, Demirbas D, Empain A, Gautschi M, Grafakou O, Grunewald S, Kingma SDK, Knerr I, Leão-Teles E, Möslinger D, Murphy E, Õunap K, Pané A, Paci S, Parini R, Rivera IA, Scholl-Bürgi S, Schwartz IVD, Sdogou T, Shakerdi LA, Skouma A, Stepien KM, Treacy EP, Waisbren S, Berry GT, Rubio-Gozalbo ME.
Front Genet. 2024 Feb 15;15:1355962. doi: 10.3389/fgene.2024.1355962. PMID: 38425716; PMCID: PMC10902464.

Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial.
Drenthen LCA, de Baaij JHF, Rodwell L, van Herwaarden AE, Tack CJ, de Galan BE.
Diabetologia. 2024 Jan;67(1):52-61. doi: 10.1007/s00125-023-06029-9. Epub 2023 Nov 3. PMID: 37922013; PMCID: PMC10709477.

Relationship between educational attainment and non-alcoholic fatty liver disease: A two-sample Mendelian randomization study.
Ren Z, Wesselius A, Stehouwer CDA, Brouwers MCGJ.
Dig Liver Dis. 2024 Apr;56(4):565-570. doi: 10.1016/j.dld.2023.11.040. Epub 2023 Dec 15. PMID: 38104027.

Association Between Low Sex Hormone-Binding Globulin and Increased Risk of Type 2 Diabetes Is Mediated by Increased Visceral and Liver Fat: Results From Observational and Mendelian Randomization Analyses.
Stangl TA, Wiepjes CM, Smit RAJ, van Hylckama Vlieg A, Lamb HJ, van der Velde JHPM, Winters-van Eekelen E, Boone SC, Brouwers MCGJ, Rosendaal FR, den Heijer M, Heijboer AC, de Mutsert R.
Diabetes. 2024 Nov 1;73(11):1793-1804. doi: 10.2337/db23-0982. PMID: 39106187.

Is cardiovascular disease in PCOS driven by MASLD?
Chen H, Simons PIHG, Brouwers MCGJ.
Trends Endocrinol Metab. 2024 Nov 7:S1043-2760(24)00273-X. doi: 10.1016/j.tem.2024.10.005. Epub ahead of print. PMID: 39510952.

Associations of 24 h time-use compositions of sitting, standing, physical activity and sleeping with optimal cardiometabolic risk and glycaemic control: The Maastricht Study.
Brakenridge CJ, Koster A, de Galan BE, Carver A, Dumuid D, Dzakpasu FQS, Eussen SJPM, Savelberg HHCM, Bosma H, Owen N, Schaper NC, Healy GN, Dunstan DW.
Diabetologia. 2024 Jul;67(7):1356-1367. doi: 10.1007/s00125-024-06145-0. Epub 2024 Apr 24. PMID: 38656371; PMCID: PMC11153304.

Fructose intake from sugar-sweetened beverages is associated with a greater risk of hyperandrogenism in women: UK Biobank cohort study.
Chen H, Buziau AM, Rentería ME, Simons PIHG, Brouwers MCGJ.
Eur J Endocrinol. 2024 Jan 3;190(1):104-112. doi: 10.1093/ejendo/lvae006. PMID: 38291515.

The effect of bolus advisors on glycaemic parameters in adults with diabetes on intensive insulin therapy: A systematic review with meta-analysis.
den Brok EJ, Svensson CH, Panagiotou M, van Greevenbroek MMJ, Mertens PR, Vazeou A, Mitrakou A, Makrilakis K, Franssen GHLM, van Kuijk S, Proennecke S, Mougiakakou S, Pedersen-Bjergaard U, de Galan BE; MELISSA consortium.
Diabetes Obes Metab. 2024 May;26(5):1950-1961. doi: 10.1111/dom.15521. Epub 2024 Mar 19. PMID: 38504142.

The impact of prior exposure to hypoglycaemia on the inflammatory response to a subsequent hypoglycaemic episode.
Verhulst CEM, van Heck JIP, Fabricius TW, Stienstra R, Teerenstra S, McCrimmon RJ, Tack CJ, Pedersen-Bjergaard U, de Galan BE; Hypo-RESOLVE consortium.
Cardiovasc Diabetol. 2024 Feb 8;23(1):55. doi: 10.1186/s12933-023-02095-w. PMID: 38331900; PMCID: PMC10854178.

Correction: Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia.
Vickneson K, Blackburn J, Gallagher JR, Evans ML, de Galan BE, Pedersen- Bjergaard U, Thorens B, McNeilly AD, McCrimmon RJ.
Diabetologia. 2024 Aug;67(8):1723. doi: 10.1007/s00125-024-06187-4. Erratum for: Diabetologia. 2021 Jun;64(6):1436-1441. doi: 10.1007/s00125-021-05425-3. PMID: 38825626; PMCID: PMC11343901.

Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency.
Buziau AM, Oosterveer MH, Wouters K, Bos T, Tolan DR, Agius L, Ford BE, Cassiman D, Stehouwer CDA, Schalkwijk CG, Brouwers MCGJ.
Mol Metab. 2024 Sep;87:101984. doi: 10.1016/j.molmet.2024.101984. Epub 2024 Jul 6. PMID: 38972375; PMCID: PMC11300931.

Magnesium Supplementation Modulates T-cell Function in People with Type 2 Diabetes and Low Serum Magnesium Levels.
Drenthen LCA, Ajie M, de Baaij JHF, Tack CJ, de Galan BE, Stienstra R.
J Clin Endocrinol Metab. 2024 Nov 18;109(12):e2240-e2245. doi: 10.1210/clinem/dgae097. PMID: 38412117; PMCID: PMC11570359.

Brain structure and connectivity mediate the association between lifestyle and cognition: The Maastricht Study.
DeJong NR, Jansen JFA, van Boxtel MPJ, Schram MT, Stehouwer CDA, van Greevenbroek MMJ, van der Kallen CJH, Koster A, Eussen SJPM, de Galan BE, Backes WH, Köhler S.
Brain Commun. 2024 May 16;6(3):fcae171. doi: 10.1093/braincomms/fcae171. PMID: 38846531; PMCID: PMC11154141.

Rare monogenic causes of steatotic liver disease masquerading as MASLD.
Brouwers MCGJ, Cassiman D.
J Hepatol. 2024 Jun;80(6):e252-e253. doi: 10.1016/j.jhep.2024.02.025. Epub 2024 Mar 6. PMID: 38458321.

Retinal microvascular function and incidence and trajectories of clinically relevant depressive symptoms: the Maastricht Study.
van Gennip ACE, Gupta MD, Houben AJHM, Berendschot TTJM, Webers CAB, van Greevenbroek MMJ, van der Kallen CJH, Koster A, Wesselius A, Eussen SJPM, Schalkwijk CG, de Galan BE, Köhler S, Schram MT, Stehouwer CDA, van Sloten TT.
Psychol Med. 2024 Jul;54(10):2482-2491. doi: 10.1017/S0033291724000618. Epub 2024 Mar 12. PMID: 38469703.

Impact of sedentary behaviour on glucose concentration in people with type 1 diabetes.
Drenthen LCA, Ajie M, Teerenstra S, Abbink EJ, Bakker EA, Thijssen DHJ, Tack CJ, de Galan BE .
Diabetes Obes Metab. 2024 Mar;26(3):1142-1143. doi: 10.1111/dom.15397. Epub 2023 Dec 11. PMID: 38073428.

Counterregulatory hormone and symptom responses to hypoglycaemia in people with type 1 diabetes, insulin-treated type 2 diabetes or without diabetes: the Hypo-RESOLVE hypoglycaemic clamp study.
Fabricius TW, Verhulst CEM, Kristensen PL, Holst JJ, Tack CJ, McCrimmon RJ, Heller SR, Evans ML, de Galan BE, Pedersen-Bjergaard U; Hypo-RESOLVE consortium.
Acta Diabetol. 2024 May;61(5):623-633. doi: 10.1007/s00592-024-02239-8. Epub 2024 Feb 20. PMID: 38376580; PMCID: PMC11055751.

Association between recent exposure to continuous glucose monitoring-recorded hypoglycaemia and counterregulatory and symptom responses to subsequent controlled hypoglycaemia in people with type 1 diabetes.
Svensson CH, Fabricius TW, Verhulst CEM, Kristensen PL, Tack CJ, Heller SR, Amiel SA, McCrimmon RJ, Evans M, Holst JJ, de Galan BE, Pedersen-Bjergaard U; Hypo‐RESOLVE consortium.
Diabetes Obes Metab. 2024 Aug;26(8):3213-3222. doi: 10.1111/dom.15649. Epub 2024 May 22. PMID: 38774963.

Reconciling the apparently contrasting observational and genetic evidence on the association between MASLD and cardiovascular disease.
Brouwers MCGJ.
J Hepatol. 2024 Nov 29:S0168-8278(24)02744-2. doi: 10.1016/j.jhep.2024.11.042. Epub ahead of print. PMID: 39617131.

Estimating risk of consequences following hypoglycaemia exposure using the Hypo-RESOLVE cohort: a secondary analysis of pooled data from insulin clinical trials.
Mellor J, Kuznetsov D, Heller S, Gall MA, Rosilio M, Amiel SA, Ibberson M, McGurnaghan S, Blackbourn L, Berthon W, Salem A, Qu Y, McCrimmon RJ, de Galan BE, Pedersen-Bjergaard U, Leaviss J, McKeigue PM, Colhoun HM.
Diabetologia. 2024 Oct;67(10):2210-2224. doi: 10.1007/s00125-024-06225-1. Epub 2024 Jul 22. PMID: 39037602; PMCID: PMC11447089.

Correction: Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes.
McNeilly AD, Gallagher JR, Evans ML, de Galan BE, Pedersen-Bjergaard U, Thorens B, Dinkova-Kostova AT, Huang JT, Ashford MLJ, McCrimmon RJ; Hypo-RESOLVE Consortium.
Diabetologia. 2024 Aug;67(8):1724. doi: 10.1007/s00125-024-06188-3. Erratum for: Diabetologia. 2023 Jul;66(7):1340-1352. doi: 10.1007/s00125-023-05907-6. PMID: 38864888; PMCID: PMC11343922.

Early life socioeconomic inequalities and type 2 diabetes incidence: Longitudinal analyses in the Maastricht study.
Meisters R, Koster A, Albers J, Sezer B, van Greevenbroek MMJ, de Galan BE, Bosma H.
Diabetes Res Clin Pract. 2024 Nov;217:111855. doi: 10.1016/j.diabres.2024.111855. Epub 2024 Sep 13. PMID: 39265827.

The interdependence of targets for continuous glucose monitoring outcomes in type 1 diabetes with automated insulin delivery.
Castañeda J, de Galan BE, van Kuijk SMJ, Arrieta A, van den Heuvel T, Cohen O.
Diabetes Obes Metab. 2024 Dec;26(12):5836-5844. doi: 10.1111/dom.15955. Epub 2024 Sep 26. PMID: 39323365.

Fructose restriction has beneficial effects on adipose tissue distribution but not on serum adipokine levels: Post-hoc analysis of a double- blind randomized controlled trial.
van Oeteren MAJ, Simons N, Simons PIHG, van de Waarenburg MPH, Kooi ME, Feskens EJM, van der Ploeg EMCL, Van den Eynde MDG, Houben AJHM, Schalkwijk CG, Brouwers MCGJ.
Clin Obes. 2024 Oct 28:e12714. doi: 10.1111/cob.12714. Epub ahead of print. PMID: 39468417.

Bone microarchitecture and strength assessed by HRpQCT in individuals with type 2 diabetes and prediabetes: the Maastricht study.
Van Hulten V, Sarodnik C, Driessen JHM, Viggers R, Rasmussen NH, Geusens PPMM, Schaper N, Schram MT, De Galan BE, Koster A, Bours SPG, Vestergaard P, Stehouwer CDA, van den Bergh JP.
JBMR Plus. 2024 Jul 3;8(9):ziae086. doi: 10.1093/jbmrpl/ziae086. PMID: 39108361; PMCID: PMC11299510.

Socioeconomic inequalities in health-related functioning among people with type 2 Diabetes: longitudinal analyses in the Maastricht Study.
Meisters R, Albers J, Sezer B, de Galan BE, Eussen SJPM, Stehouwer CDA, Schram MT, van Greevenbroek MMJ, Wesselius A, Koster A, Bosma H.
BMC Public Health. 2024 Jan 3;24(1):73. doi: 10.1186/s12889-023-17553-z. PMID: 38172697; PMCID: PMC10763122.

Activation of the HPA axis does not explain non- responsiveness to GLP-1R agonist treatment in individuals with type 2 diabetes.
Tokgöz S, Boss M, Jansen TJ, Meijer R, Frielink C, van Bon AC, Tack CJ, de Galan BE, Gotthardt M.
Diabetes. 2024 Nov 19:db240463. doi: 10.2337/db24-0463. Epub ahead of print.

Validation of radiolabelled exendin for beta cell imaging by ex vivo autoradiography and immunohistochemistry of human pancreas.
Jansen TJP, Tokgöz S, Buitinga M, van Lith SAM, Joosten L, Frielink C, Smeets EMM, Stommel MWJ, van der Kolk MB, de Galan BE, Brom M, Boss M, Gotthardt M.
EJNMMI Res. 2024 Oct 15;14(1):96. doi: 10.1186/s13550-024-01159-6. PMID: 39405026; PMCID: PMC11480297.

Development of a new health-related quality of life measure for people with diabetes who experience hypoglycaemia: the Hypo-RESOLVE QoL.
Carlton J, Powell PA, Broadley M, de Galan BE, Heller S, Comins J, Rosilio M, Pouwer F, Gall MA, Child CJ, McCrimmon RJ, Rowen D.
Diabetologia. 2024 Aug;67(8):1536-1551. doi: 10.1007/s00125-024-06182-9. Epub 2024 May 22. PMID: 38777868; PMCID: PMC11343818.

Cross-sectional associations between patterns and composition of upright and stepping events with physical function: insights from The Maastricht Study.
Culverhouse J, Hillsdon M, Koster A, Bosma H, de Galan BE, Savelberg HHCM, Pulsford R.
Eur Rev Aging Phys Act. 2024 May 9;21(1):10. doi: 10.1186/s11556-024-00343-w. PMID: 38724917; PMCID: PMC11080173.

Volatile organic compounds in exhaled breath, blood, and urine detected in patients with thyroid carcinoma using gas chromatography-ion mobility spectrometry - a pilot study.
Al-Difaie ZJJ, Scheepers MHMC, Engelen SME, Lubbers T, Havekes B, Bouvy ND.
J Breath Res. 2024 Nov 26;19(1). doi: 10.1088/1752-7163/ad89ef. PMID: 39437815.

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