Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. 
Wefers J, van Moorsel D, Hansen J, Connell NJ, Havekes B, Hoeks J, van Marken Lichtenbelt WD, Duez H, Phielix E, Kalsbeek A, Boekschoten MV, Hooiveld GJ, Hesselink MKC, Kersten S, Staels B, Scheer FAJL, Schrauwen P. 
Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7789-7794. doi: 10.1073/pnas.1722295115

DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment.
Conemans EB, Lodewijk L, Moelans CB, Offerhaus GJA, Pieterman CRC, Morsink FH, Dekkers OM, de Herder WW, Hermus AR, van der Horst-Schrivers AN, Drent ML, Bisschop PH, Havekes B, Brosens LAA, Dreijerink KMA, Borel Rinkes IHM, Timmers HTM, Valk GD, Vriens MR. 
Eur J Endocrinol. 2018 Sep;179(3):153-160. doi: 10.1530/EJE-18-0195

Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes.
de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Schrauwen-Hinderling VB, van Marken Lichtenbelt W, Schrauwen P. 
Mol Metab. 2018 Jun;12:39-47. doi:10.1016/j.molmet.2018.04.004.

High Fear of Disease Occurrence Is Associated With Low Quality of Life in Patients With Multiple Endocrine Neoplasia Type 1: Results From the Dutch MEN1 Study Group.
van Leeuwaarde RS, Pieterman CRC, Bleiker EMA, Dekkers OM, van der Horst-Schrivers AN, Hermus AR, de Herder WW, Drent ML, Bisschop PH, Havekes B, Vriens MR, Valk GD. 
J Clin Endocrinol Metab. 2018 Jun 1;103(6):2354-2361. doi: 10.1210/jc.2018-00259.

The effects of angiotensin receptor neprilysin inhibition by sacubitril/valsartan on adipose tissue transcriptome and protein expression in obese hypertensive patients.
Stinkens R, van der Kolk BW, Jordan J, Jax T, Engeli S, Heise T, Jocken JW, May M, Schindler C, Havekes B, Schaper N, Albrecht D, Kaiser S, Hartmann N, Letzkus M, Langenickel TH, Goossens GH, Blaak EE. 
Sci Rep. 2018 Mar 2;8(1):3933. doi: 10.1038/s41598-018-22194-z.

Psychosocial development in survivors of childhood differentiated thyroid carcinoma: a cross-sectional study.
Nies M, Dekker BL, Sulkers E, Huizinga GA, Klein Hesselink MS, Maurice-Stam H, Grootenhuis MA, Brouwers AH, Burgerhof JGM, van Dam EWCM, Havekes B, van den Heuvel-Eibrink MM, Corssmit EPM, Kremer LCM, Netea-Maier RT, an der Pal HJH, Peeters RP, Plukker JTM, Ronckers CM, van Santen HM, van der Horst-Schrivers ANA, Tissing WJE, Bocca G, Links TP. 
Eur J Endocrinol. 2018 Mar;178(3):215-223. doi: 10.1530/EJE-17-0741.

Effect of Sacubitril/Valsartan on Exercise-Induced Lipid Metabolism in Patients With Obesity and Hypertension.
Engeli S, Stinkens R, Heise T, May M, Goossens GH, Blaak EE, Havekes B, Jax T, Albrecht D, Pal P, Tegtbur U, Haufe S, Langenickel TH, Jordan J.
Hypertension. 2018 Jan;71(1):70-77. doi:10.1161/HYPERTENSIONAHA.117.10224.

Expression of p27(Kip1) and p18(Ink4c) in human multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors.
Conemans EB, Raicu-Ionita GM, Pieterman CRC, Dreijerink KMA, Dekkers OM, Hermus AR, de Herder WW, Drent ML, van der Horst-Schrivers ANA, Havekes B, Bisschop PH, Offerhaus GJ, Borel Rinkes IHM, Valk GD, Timmers HTM, Vriens MR.
J Endocrinol Invest. 2018 Jun;41(6):655-661. doi: 10.1007/s40618-017-0783-y.

Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver.
Brouwers B, Schrauwen-Hinderling VB, Jelenik T, Gemmink A, Sparks LM, Havekes B, Bruls Y, Dahlmans D, Roden M, Hesselink MKC, Schrauwen P. 
Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E165-E173. doi:10.1152/ajpendo.00266.2017.

In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes.
Ratter JM, Rooijackers HMM, Hooiveld GJ, Hijmans AGM, de Galan BE, Tack CJ, Stienstra R.
Front Immunol. 2018;9:2564. doi: 10.3389/fimmu.2018.02564. eCollection 2018.

Genetic determinants of impaired awareness of hypoglycemia in type 1 diabetes.
Schouwenberg BJ, de Galan BE.
Pharmacogenet Genomics. 2018;28(8):196-197.

Hypoglycaemia induces recruitment of non-classical monocytes and cytotoxic lymphocyte subsets in type 1 diabetes.
Ratter JM, Rooijackers HMM, Jacobs CWM, de Galan BE, Tack CJ, Stienstra R.
Diabetologia. 2018;61(9):2069-2071

Effect of lactate administration on brain lactate levels during hypoglycemia in patients with type 1 diabetes.
Wiegers EC, Rooijackers HM, Tack CJ, Philips BW, Heerschap A, van der Graaf M, de Galan BE.
J Cereb Blood Flow Metab. 2019;39(10):1974-1982.

Effect of Automated Bolus Calculation on Glucose Variability and Quality of Life in Patients With Type 1 Diabetes on CSII Treatment.
van Meijel LA, van den Heuvel-Bens SP, Zimmerman LJ, Bazelmans E, Tack CJ, de Galan BE.
Clin Ther. 2018;40(6):862-871.

Patients with type 1 diabetes mellitus have impaired IL-1β production in response to Mycobacterium tuberculosis.
Lachmandas E, Thiem K, van den Heuvel C, Hijmans A, de Galan BE, Tack CJ, Netea MG, van Crevel R, van Diepen JA.
Eur J Clin Microbiol Infect Dis. 2018;37(2):371-380.

Prediabetes Is Associated With Structural Brain Abnormalities: The Maastricht Study.
van Agtmaal MJM, Houben AJHM, de Wit V, Henry RMA, Schaper NC, Dagnelie PC, van der Kallen CJ, Koster A, Sep SJ, Kroon AA, Jansen JFA, Hofman PA, Backes WH, Schram MT, Stehouwer CDA.
Diabetes Care. 2018;41:2535-2543. IF 13.397.

Social Network Characteristics Are Associated With Type 2 Diabetes Complications: The Maastricht Study. Diabetes Care.
Brinkhues S, Dukers-Muijrers NHTM, Hoebe CJPA, van der Kallen CJH, Koster A, Henry RMA, Stehouwer CDA, Savelkoul PHM, Schaper NC, Schram MT.
2018;41:1654-1662. IF 13.397.

Development of prediction models for upper and lower respiratory and gastrointestinal tract infections using social network parameters in middle-aged and older persons: The Maastricht Study.
Brinkhues S, van Kuijk S, Hoebe C, Savelkoul P, Kretzschmar MEE, Jansen M, de Vries N, Sep S, Dagnelie P, Schaper N, Verhey F, Bosma H, Maes J, Schram M, Dukers N.
Epidemiology and Infection. 2018;146(5):533-543. IF 2.044.

Macular thinning in prediabetes or type 2 diabetes without diabetic retinopathy: the Maastricht Study.
De Clerck EEB, Schouten JSAG, Berendschot TTJM, Goezinne F, Dagnelie PC, Schaper NC, Schram MT, Stehouwer CDA, Webers CAB. 
Acta Ophthalmologica. 2018;96(2)174-182. IF 3.324.

Risk of a first-ever acute myocardial infarction and all-cause mortality with sulphonylurea treatment: A population-based cohort study.
van Dalem J, Brouwers MCGJ, Stehouwer CDA, Krings A, Klungel OH, Driessen JHM, de Vries F, Burden AM.
Diabetes Obesity & Metabolism. 2018;20(4):1056-1060. IF 5.980.

Reducing sitting time versus adding exercise: differential effects on biomarkers of endothelial dysfunction and metabolic risk.
Duvivier BMFM, Bolijn JE, Koster A, Schalkwijk CG, Savelberg HHCM, Schaper NC.
Scientific Reports. 2018;8(1):8657. IF 4.122.

Carotid circumferential wall stress is not associated with cognitive performance among individuals in late middle age: The Maastricht Study.
Geijselaers SLC, Sep SJS, Schram MT, van Boxtel MPJ, van Sloten TT, Roodt JOH, Henry RMA, Reesink KD, Schaper NC, Dagnelie PC, van der Kallen CJH, Biessels GJ, Stehouwer CDA. 
Atherosclerosis. 2018;276:15-22. IF 4.467.

A risk score including body mass index, glycated haemoglobin and triglycerides predicts future glycaemic control in people with type 2 diabetes.
Hertroijs DFL, Elissen AMJ, Brouwers MCGJ, Schaper NC, Köhler S, Popa MC, Asteriadis S, Hendriks SH, Bilo HJ, Ruwaard D. 
Diabetes, Obesity and Metabolism. 2018;20(3):681-688. IF 5.980.

The impact of metabolic control and tetrahydrobiopterin treatment on health related quality of life of patients with early-treated phenylketonuria: A PKU-COBESO study.
Huijbregts SCJ, Bosch AM, Simons QA, Jahja R, Brouwers MCGJ, De Sonneville LMJ, De Vries MC, Hofstede FC, Hollak CEM, Janssen MCH, Langendonk JG, Rubio-Gozalbo ME, Van der Meere JJ, Van der Ploeg AT, Van Spronsen FJ. 
Molecular Genetics and Metabolism. 2018;125:96-103. IF 3.774.

Albuminuria is associated with a higher prevalence of depression in a population-based cohort study: the Maastricht Study.
Martens RJH, Kooman JP, Stehouwer CDA, Dagnelie PC, van der Kallen CJH, Kroon AA, Leunissen KML, van der Sande FM, Schaper NC, Sep SJS, Kohler S, Schram MT, Henry RMA. 
Nephrology Dialysis Transplantation. 2018;33(1):128-138. IF 4.600.

Amount and pattern of physical activity and sedentary behavior are associated with kidney function and kidney damage: The Maastricht Study.
Martens RJH, van der Berg JD, Stehouwer CDA, Henry RMA, Bosma H, Dagnelie PC, van Dongen MCJM, Eussen SJPM, Schram MT, Sep SJS, van der Kellen CJH, Schaper NC, Savelberg HHCM, van der Sande FM, Kroon AA, Kooman JP, Koster A.
PLOS ONE. 2018;13(4):e0195306. IF 2.766.

Microvascular endothelial dysfunction is associated with albuminuria: the Maastricht Study.
Martens RJH, Houben AJHM, Kooman JP, Berendschot TTJM, Dagnelie PC, van der Kallen CJH, Kroon AA, Leunissen KML, van der Sande FM, Schaper NC, Schouten JSAG, Schram MT, Sep SJS, Sörensen BM, Henry RMA, Stehouwer CDA.
Journal of Hypertension. 2018;36(5):1178-1187. IF 4.092.

Management of MEN1 Related Nonfunctioning Pancreatic NETs: A Shifting Paradigm: Results From the DutchMEN1 Study Group.
Nell S, Verkooijen HM, Pieterman CRC, de Herder WW, Hermus AR, Dekkers OM, van der Horst-Schrivers AN, Drent ML, Bisschop PH, Havekes B, Rinkes IHMB, Vriens MR, Valk GD. 
Annals of Surgery. 2018;267:1155-1160. IF 9.203.

Arterial stiffness is associated with depression in middle-aged men - the Maastricht Study.
Onete V, Henry RM, Sep SJS, Koster A, van der Kallen CJ, Dagnelie PC, Schaper N, Kohler S, Reesink K, Stehouwer CDA, Schram MT. 
Journal of Psychiatry & Neuroscience. 2018;43(2):111-119. IF 5.182.

Diabet Peart Parelsnoer Initiative. High Diabetes Distress Among Ethnic Minorities Is Not Explained by Metabolic, Cardiovascular, or Lifestyle Factors: Findings From the Dutch Diabetes Pearl Cohort.
Ozcan B, Rutters F, Snoek FJ, Roosendaal M, Sijbrands EJ, Elders PJM, Holleman F, Pijl H, Tack CJ, Abbink EJ, de Valk HW, Wolffenbuttel BHR, Stehouwer CDA, Schaper NC, Dekker JM, Schram MT. 
Diabetes Care. 2018;41:1854-1861. IF 13.397.

Association Between Employment Status and Objectively Measured Physical Activity and Sedentary BehaviorThe Maastricht Study.
Pulakka A, Stenholm S, Bosma H, Schaper NC, Savelberg HHCM, Stehouwer CDA, van der Kallen CJH, Dagnelie PC, Sep SJS, Koster A. 
Journal of Occupational and Environmental Medicine. 2018;60(4):309-315. IF 1.355.

The risks of sarcopenia, falls and fractures in patients with type 2 diabetes mellitus.
Sarodnik C, Bours SPG, Schaper NC, van den Bergh JP, van Geel TACM. 
Maturitas. 2018;109:70-77. IF 3.315.

Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis.
Simons PIHG, Simons N, Stehouwer CDA, Schalkwijk CG, Schaper NC, Brouwers MCGJ. 
PLOS ONE. 2018;13:0206174. IF 2.766.

Which is more important for cardiometabolic health: sedentary time, higher intensity physical activity or cardiorespiratory fitness?
van der Velde JHPM, Schaper NC, Stehouwer CDA, van der Kallen CJH, Sep SJS, Schram MT, Henry RMA, Dagnelie PC, Eussen SJPM, van Dongen MCJM, Savelberg HHCM, Koster A.
The Maastricht Study. Diabetologia. 2018;61:2561-2569. IF 6.023.

Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50years or older.
van der Velde RY, Wyers CE, Geusens PPMM, van den Bergh JPW, de Vries F, Cooper C, van de Staa TP, Harvey NC. 
Osteoporosis International. 2018;29(11):2469-2475. IF 3.856.

A web-based program to improve treatment adherence in patients with type 2 diabetes: Development and study protocol.
Vluggen S, Hoving C, Schaper NC, de Vries H. 
Contemporary Clinical Trials. 2018;74:38-45. IF 2.658.

Exploring beliefs on diabetes treatment adherence among Dutch type 2 diabetes patients and healthcare providers.
Vluggen S, Hoving C, Schaper NC, de Vries H. 
Patient Education and Counseling. 2018;101(1):92-98. IF 2.785.

Reliability of HR-pQCT Derived Cortical Bone Structural Parameters When Using Uncorrected Instead of Corrected Automatically Generated Endocortical Contours in a Cross-Sectional Study: The Maastricht Study
de Waard EAC, Sarodnik C, Pennings A, de Jong JJA, Savelberg HHCM, van Geel TA, van der Kallen CJ, Stehouwer CDA, Schram MT, Schaper N, Dagnelie PC, Geusens PPMM, Koster A, van Rietbergen B, van den Bergh JPW.
Calcified Tissue International. 2018;103(3):252-265. IF 3.293.

The association between diabetes status, HbA1c, diabetes duration, microvascular disease, and bone quality of the distal radius and tibia as measured with highresolution peripheral quantitative computed tomography: The Maastricht Study.
de Waard EAC, de Jong JJA, Koster A, Savelberg HHCM, van Geel TA, Houben AJHM, Schram MT, Dagnelie PC, van der Kallen CJ, Sep SJS, Stehouwer CDA, Schaper NC, Berendschot TTJM, Schouten JSAG, Geusens PPMM, van den Bergh JPW. 
Osteoporosis International. 2018;29(12):2725-2738. IF 3.856.

 'Quality in, quality out', a stepwise approach to evidence-based medicine for rare diseases promoted by multiple endocrine neoplasia type 1.
van Beek DJ, van Leeuwaarde RS, Pieterman CRC, Vriens MR, Valk GD, Bisschop PH, Rinkes IHMB, Dekkers OM, Drent ML, Havekes B, de Herder WW, Hermus ARMM, van der Horst-Schrivers ANA, de Jong J, Vasen HFA, Zonnenberg BA, DutchMEN Study Group.
Endocrine Connections. 2018;7:R260-R274.

Non-alcoholic fatty liver disease concerns with glucokinase activators.
Hodson L, Brouwers MCGJ. 
The Lancet Diabetes & Endocrinology. 2018;6(9):684-685. IF 19.313.

Association of type 2 diabetes mellitus with self-reported knee pain and clinical knee osteoarthritis: The Maastricht Study.
Nielen JTH, Emans PJ, van den Bemt B, Dagnelie PC, Schram MT, Stehouwer CDA, Schaper NC, Denissen KFM, de Vries F, Boonen A. 
Diabetes & Metabolism. 2018;44(3):296-299. IF 3.744.

Relevant patient characteristics for guiding tailored integrated diabetes primary care: a systematic review.
Hertroijs DFL, Elissen AMJ, Brouwers MC, Schaper NC, Ruwaard D.
Prim Health Care Res Dev. 2018 Feb 6:1-24.

Associations between advanced glycation endproducts and matrix metalloproteinases and its inhibitor in individuals with type 1 diabetes.
Peeters SA, Engelen L, Buijs J, Theilade S, Rossing P, Schalkwijk CG, Stehouwer CDA.
J Diabetes Complications. 2018 Mar;32(3):325-329.

Correction: Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis-A Cohort Study in a Group of Thyroid Carcinoma Patients.
Broeders EPM, Vijgen GHEJ, Havekes B, Bouvy ND, Mottaghy FM, Kars M, Schaper NC, Schrauwen P, Brans B, van Marken Lichtenbelt WD.
PLoS One. 2018 Dec 12;13(12):e0209225. doi: 10.1371/journal.pone.0209225.

Long-term effects of radioiodine treatment on salivary gland function in adult survivors of pediatric differentiated thyroid carcinoma.
Selvakumar T, Nies M, Klein Hesselink MS, Brouwers AH, van der Horst-Schrivers ANA, Klein Hesselink EN, Tissing WJE, Vissink A, Links TP, Bocca G, Burgerhof JGM, van Dam EWCM, Havekes B, van den Heuvel-Eibrink MM, Corssmit EPM, Kremer LCM, Netea-Maier RT, van der Pal HJH, Peeters RP, Smit JWA, Plukker JTM, Ronckers CM, van Santen HM.
J Nucl Med. 2018 Nov 30. pii: jnumed.118.212449. doi: 10.2967/jnumed.118.212449.

Thyroid Gland (18)F-FDG Uptake in Neurofibromatosis Type 1.
van Lierop ZYGJ, Jentjens S, Anten MHME, Wierts R, Stumpel CT, Havekes B, van Kroonenburgh MJPG. 
Eur Thyroid J. 2018 Jun;7(3):155-161. doi: 10.1159/000488706.

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